- Isabella "Bella" Swan - Kristen Stewart
- Edward Cullen - Robert Pattinson
- Charlie Swan - Billy Burke
- Dr. Carlisle Cullen - Peter Facinelli
- Alice Cullen - Ashley Greene
- Rosalie Cullen - Nikki Reed
- Jasper Cullen - Jackson Rathbone
- Emmett Cullen - Kellan Lutz
- Esme Cullen - Elizabeth Reaser
- Victoria - Rachelle LeFevre
- Laurent - Edi Gathegi
- Jessica Stanley - Anna Kendrick
- Mike Newton - Michael Welch
- Eric Yorkie - Justin Chon
- Angela Weber - Christian Serratos
- Rene - Sarah Clarke
- Tyler Gregory - Tyree Boyce

Les Volturis
- Aro - Michael Sheen
- Caius - Jamie Campbell Bower
- Marcus - Christopher Heyerdahl
- Demetri - Charlie Bewley
- Felix - Daniel Cudmore
- Jane - Dakota Fanning
- Alec - Cameron Bright
- Heidi - Noot Seear

Les Quileutes
- Jacob Black - Taylor Lautner
- Sam Uley - Chaske Spencer
- Quil Ateara - Tyson Houseman
- Paul - Alex Meraz
- Embry Call - Kiowa Gordon
- Jared - Bronson Pelletier
- Billy Black - Gil Birmingham
- Harry Clearwater - Graham Greene
- Emily - Tinsel Korey